






Keep your dog protected with the number 1 name in flea & tick protection (1), FRONTLINE. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that’s proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years (2) — FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog’s entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: (1) BI Marketing Excellence Survey performed by Kynetec, November 2023. (2) 20 years of trust in killing fleas and ticks demonstrated by various studies in the past 20 years including a 2002 Pet Owner Brand Awareness and Attitude Tracking Study performed by Bruno and Ridgway Research Associates and the 2023 BrandSpark© American Trust Study where FRONTLINE Brand Products were voted most trusted for brand for flea & tick prevention.
Is Discontinued By Manufacturer : No
Product Dimensions : 5.75 x 0.75 x 4.5 inches; 0.64 ounces
Manufacturer recommended age : 1 month and up
Item model number : 72219
Department : Insect Control
Date First Available : September 2, 2004
Manufacturer : Boehringer Ingelheim Animal Health
ASIN : B0002J1FOE
Best Sellers Rank: #337 in Pet Supplies (See Top 100 in Pet Supplies) #1 in Dog Flea Drops
Customer Reviews: 4.4 4.4 out of 5 stars (49,074) var dpAcrHasRegisteredArcLinkClickAction; P.when(‘A’, ‘ready’).execute(function(A) { if (dpAcrHasRegisteredArcLinkClickAction !== true) { dpAcrHasRegisteredArcLinkClickAction = true; A.declarative( ‘acrLink-click-metrics’, ‘click’, { “allowLinkDefault”: true }, function (event) { if (window.ue) { ue.count(“acrLinkClickCount”, (ue.count(“acrLinkClickCount”) || 0) + 1); } } ); } }); P.when(‘A’, ‘cf’).execute(function(A) { A.declarative(‘acrStarsLink-click-metrics’, ‘click’, { “allowLinkDefault” : true }, function(event){ if(window.ue) { ue.count(“acrStarsLinkWithPopoverClickCount”, (ue.count(“acrStarsLinkWithPopoverClickCount”) || 0) + 1); } }); });
Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that’s proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus
Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus
11 reviews for FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments
Add a review
$39.98

LiisaFreja –
Good for little dogs
Have used Frontline for years. Works and it doesn’t make the dogs sick.
Donna –
No more fleas!
No issues at all with this product works as advertised no fleas after treatment!
tyler kent –
Amazing!
We recently had a very sudden breakout with fleas on our dogs and within a couple of weeks they were horrible! We couldnt get rid of them for anything (even tried capstar but didn’t seem to make a difference in at least getting to to where it was manageable) I decided to give over the counter flea meds another shot and ordered this stuff. Thank god I did!! We put it on the dogs around 1-2pm today and I noticed a couple of fleas fall off. But, after that I didn’t notice much of anything. I checked them again (10pm) expecting to see fleas all over my poor dog.. to my surprise I dont see a single flea! We will definitely be putting this on auto ship. I highly recommend this stuff!
Smile chilla –
Not as great on the chewing lice
Claims to kill chewing lice too.. my senior dogs never leave my fenced yard but somehow get these. But your product doesnt work as fast or completely as it used to. Thats why 4 star vs 5
Amazon Customer –
Tried and true product for Lyme disease prevention
Tried and true product. As a general rule, I do not like having to put chemicals on my dogs. But we live in an area where the ticks are atrocious and some years are worse than others. So I struggle with putting chemicals on the dogs versus having them contract Lyme disease so I do use this product when I feel that I have to. I have never had a dog have a reaction to Frontline, and we have had dogs for 25 years. It works immediately. I wish they would come out with a product like this for people. I had a tick crawling down my neck the other day and it really freaked me out.Good price and fast shipping.
Abigail –
Works fast!
Works so good and fast! My two big dogs were having issues with fleas and ticks. I put the medicine on and they looked so much better within a day! I haven’t actually reapplied it for the last couple months and they still look great.
Sheryl –
Didn’t prevent fleas but Seresto collar did
The Frontline Plus flea and tick control for 45 to 88 pound dogs was worse than a disappointment. My dog is 50 pounds–well within the dosage range and become infested with fleas during the second month/dosage of usage. I’m not sure if the preventative actually worked the first month or if I just didn’t notice the fleas until the fleas had multiplied enough for me to easily see them. I also don’t know if I received the same quailty Frontline product through Amazon as a store/vet purchase. I have no reason to think that this was an imitation product other than some suspicions by other reviewers. Regardless, I had to use a flea dip and flea bomb my house. Once an infestation occurs, getting rid of the fleas is quite an aggravation. I’m trying Advantage II from PetSmart now to see if that will work. Hopefully, something will.June 24 2013, Advantage II didn’t work either. I’ve had acceptable success from Certifect which I buy from my vet. I’ve used Certifect for over a year now. These flea and tick drops are made by Frontline but are only sold by prescription or thru a vetinarian. It works great for ticks. I’ve not had any problems with ticks from the first dosage. For a few days, though, after the dosage, he is a bit lethargic. However, my dog will still pick up fleas. The drops do kill the fleas but don’t repel them quickly enough. Many people are having trouble with fleas because of the sucession of mild winters. The flea population isn’t culled enough. During the summer months, the fleas just seem to overwhelm the medication and flea dips or additional organic sprays are necessary. I’ve been told that a new flea and tick pill may now be available. I know the flea pill works but I hadn’t used it because I needed something for ticks. If this rumor is true, I’ll definately give the pill a try.December 30, 2014. I finally found something that actually works for controlling fleas and ticks for my now 70 pound Labrador/mix. (He was a stray that my family adopted–short hair.) My vet introduced me to a new product (at the time) made by Bayer. It’s a flea collar called Seresto that is sold on Amazon. I couldn’t believe that a flea collar would really work. But, after having to hire Orkin to get the fleas out of my home, I was willing to try it. It’s the best product that I have used for fleas and ticks. It’s easy to use. I just put the collar on my dog. In few days all fleas were gone. The only ticks I ever find on my dog are the ones that he picks up during a walk or bush adventure. They are easily brushed off (when I notice them) and never attach. The collar lasts as long as advertised–8 months or in our case 5 months since he likes to swim. Unlike the drops, he is never lethargic afterwards. I have used several of these Seresto collars now and can’t recommend them enough. They are sold on Amazon, by veterinarians, and I’ve seen them at Pet Smart as well.
Douglas fernandes –
It was very helpful I managed to get control of the continue scratching on her back
Ava Alipanah –
Very excellent and high quality
Sen Sen –
It works
Ashley P –
My dog got extremely ill for 3 days afterwards . Seller doesn’t allow returns!